Publications

2024

Nakamura Y, Shimada IS, Maroofian R, Falabella M, Zaki MS, Fujimoto M, Sato E, Takase H, Aoki S, Miyauchi A, Koshimizu E, Miyatake S, Arioka Y, Honda M, Higashi T, Miya F, Okubo Y, Ogawa I, Scardamaglia A, Miryounesi M, Alijanpour S, Ahmadabadi F, Herkenrath P, Dafsari HS, Velmans C, Al Balwi M, Vitobello A, Denommé-Pichon AS, Jeanne M, Civit A, Abdel-Hamid MS, Naderi H, Darvish H, Bakhtiari S, Kruer MC, Carroll CJ, Ghayoor Karimiani E, Khailany RA, Abdulqadir TA, Ozaslan M, Bauer P, Zifarelli G, Seifi T, Zamani M, Al Alam C, Alvi JR, Sultan T, Efthymiou S, Pope SAS, Haginoya K, Matsunaga T, Osaka H, Matsumoto N, Ozaki N, Ohkawa Y, Oki S, Tsunoda T, Pitceathly RDS, Taketomi Y, Houlden H, Murakami M, Kato Y, Saitoh S. Biallelic null variants in PNPLA8 cause microcephaly by reducing the number of basal radial glia. Brain. 2024 Jul 31:awae185. doi: 10.1093/brain/awae185. Epub ahead of print. PMID: 39082157.
Jargalsaikhan BE, Muto M, Been Y, Matsumoto S, Okamura E, Takahashi T, Narimichi Y, Kurebayashi Y, Takeuchi H, Shinohara T, Yamamoto R, Ema M. The Dual-Pseudotyped Lentiviral Vector with VSV-G and Sendai Virus HN Enhances Infection Efficiency through the Synergistic Effect of the Envelope Proteins. Viruses. 2024 May 23;16(6):827. doi: 10.3390/v16060827. PMID: 38932120; PMCID: PMC11209056.
Nakai R, Yokota T, Tokunaga M, Takaishi M, Yokomizo T, Sudo T, Shi H, Yasumizu Y, Okuzaki D, Kokubu C, Tanaka S, Takaoka K, Yamanishi A, Yoshida J, Watanabe H, Kondoh G, Horie K, Hosen N, Sano S, Takeda J. A newly identified gene Ahed plays essential roles in murine haematopoiesis. Nat Commun. 2024 Jun 25;15(1):5090. doi: 10.1038/s41467-024-49252-7. PMID: 38918373; PMCID: PMC11199565.
Harasimov K, Gorry RL, Welp LM, Penir SM, Horokhovskyi Y, Cheng S, Takaoka K, Stützer A, Frombach AS, Taylor Tavares AL, Raabe M, Haag S, Saha D, Grewe K, Schipper V, Rizzoli SO, Urlaub H, Liepe J, Schuh M. The maintenance of oocytes in the mammalian ovary involves extreme protein longevity. Nat Cell Biol. 2024 Jun 20. doi: 10.1038/s41556-024-01442-7. Epub ahead of print. PMID: 38902423.
Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, Liu Y, Goto K, Kani K, Uchida R, Takeda N, Morita H, Xiao Y, Hayashi M, Maru Y, Hasumi E, Kojima T, Ishiguro S, Kijima Y, Yachie N, Yamazaki S, Yamamoto R, Kudo F, Nakanishi M, Iwama A, Fujiki R, Kaneda A, Ohara O, Nagai R, Manabe I, Komuro I. Heart failure promotes multimorbidity through innate immune memory. Sci Immunol. 2024 May 24;9(95):eade3814. doi: 10.1126/sciimmunol.ade3814. Epub 2024 May 24. PMID: 38787963.
Hayashi Y, Hashimoto M, Takaoka K, Takemoto T, Takakura N, Kidoya H. Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling. In Vitro Cell Dev Biol Anim. 2024 Apr 16. doi: 10.1007/s11626-024-00899-y. Epub ahead of print. PMID: 38625488.
Yoneda Y, Kato H, Maezawa Y, Yokote K, Nakanishi M, Real-time imaging of human endothelial-to-hematopoietic transition in vitro using pluripotent stem cell derived hemogenic endothelium, Biophysics and Physicobiology, Article ID e211015, Advance online publication March 22, 2024, Online ISSN 2189-4779, https://doi.org/10.2142/biophysico.bppb-v21.s015
Hashimoto M, Kojima Y, Sakamoto T, Ozato Y, Nakano Y, Abe T, Hosoda K, Saito H, Higuchi S, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Hata T, Nagayama S, Kagawa K, Goto Y, Utou M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Takahashi K, Niida A, Hirose H, Hayashi S, Koseki J, Fukuchi S, Murakami K, Yoshizumi T, Kadomatsu K, Tobo T, Oda Y, Uemura M, Eguchi H, Doki Y, Mori M, Oshima M, Shibata T, Suzuki Y, Shimamura T, Mimori K. Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis. EBioMedicine. 2024 Apr 9:105102. doi: 10.1016/j.ebiom.2024.105102. Epub ahead of print. PMID: 38614865.
Kojima Y, Mii S, Hayashi S, Hirose H, Ishikawa M, Akiyama M, Enomoto A, Shimamura T. Single-cell colocalization analysis using a deep generative model. Cell Syst. 2024 Feb 21;15(2):180-192.e7. doi: 10.1016/j.cels.2024.01.007. PMID: 38387441.

2023

Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, Wang K, Hirose H, Sasahara A, Yano M, Ishikawa S, Inokuchi M, Ota T, Tanabe M, Tada KI, Akiyama T, Cheng X, Liu CC, Yamashita T, Sugano S, Uchida Y, Chiba T, Asahara H, Nakagawa M, Sato S, Miyagi Y, Shimamura T, Nagai LAE, Kanai A, Katoh M, Nomura S, Nakato R, Suzuki Y, Tojo A, Voon DC, Ogawa S, Okamoto K, Foukakis T, Gotoh N. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. J Clin Invest. 2023 Nov 15;133(22):e166666. doi: 10.1172/JCI166666. PMID: 37966117; PMCID: PMC10645391.
Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, Sugaya M, Hibino S, Nishida M, Hasegawa M, Morita H, Ando R, Tsuchida R, Yoshida M, Kodama T, Yanai H, Shimamura T, Osawa T. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus. 2023 Oct 10;2(10):pgad306. doi: 10.1093/pnasnexus/pgad306. PMID: 37822765; PMCID: PMC10563787.
Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, Sakamoto DM, Kojima Y, Nishida M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y, Yanai H, Takano H, Yao R, Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, Osawa T. Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth. EMBO J. 2023 Nov 15;42(22):e114032. doi: 10.15252/embj.2023114032. Epub 2023 Oct 2. PMID: 37781951; PMCID: PMC10646561.
Takashima S, Okamura E, Ichiyama Y, Nishi K, Shimizu A, Watanabe C, Muto M, Matsumoto S, Tsukiyama-Fujii S, Tsukiyama T, Ogita H, Nishi E, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Mizutani KI, Ema M. Null mutation of exocyst complex component 3-like does not affect vascular development in mice. Exp Anim. 2023 Sep 1. doi: 10.1538/expanim.23-0105. Epub ahead of print. PMID: 37661429.
Orlando L, Benoit YD, Reid JC, Nakanishi M, Boyd AL, García-Rodriguez JL, Tanasijevic B, Doyle MS, Luchman A, Restall IJ, Bergin CJ, Masibag AN, Aslostovar L, Di Lu J, Laronde S, Collins TJ, Weiss S, Bhatia M. Chemical genomics reveals targetable programs of human cancers rooted in pluripotency. Cell Chem Biol. 2023 Jul 20;30(7):780-794.e8. doi: 10.1016/j.chembiol.2023.06.004. Epub 2023 Jun 27. PMID: 37379846.
Matsumoto S, Okamura E, Muto M, Ema M. Similarities and differences in placental development between humans and cynomolgus monkeys. Reprod Med Biol. 2023 Jun 26;22(1):e12522. doi: 10.1002/rmb2.12522. PMID: 37377753; PMCID: PMC10292683.
Koseki J, Hayashi S, Kojima Y, Hirose H, Shimamura T. Topological data analysis of protein structure and inter/intra-molecular interaction changes attributable to amino acid mutations. Comput Struct Biotechnol J. 2023 May 9;21:2950-2959. doi: 10.1016/j.csbj.2023.05.009. PMID: 37228703; PMCID: PMC10205437.
Tsujimura N, Ogino T, Hiraki M, Kai T, Yamamoto H, Hirose H, Yokoyama Y, Sekido Y, Hata T, Miyoshi N, Takahashi H, Uemura M, Mizushima T, Doki Y, Eguchi H, Yamamoto H. Super Carbonate Apatite-miR-497a-5p Complex Is a Promising Therapeutic Option against Inflammatory Bowel Disease. Pharmaceuticals (Basel). 2023 Apr 19;16(4):618. doi: 10.3390/ph16040618. PMID: 37111375; PMCID: PMC10146939.
Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H, Takaoka K, Nishimura O, Kuraku S, Tanaka S, Hamada H. Gse1, a component of the CoREST complex, is required for placenta development in the mouse. Dev Biol. 2023 Apr 4;498:97-105. doi: 10.1016/j.ydbio.2023.03.009. Epub ahead of print. PMID: 37019373.
Itakura H, Hata T, Okuzaki D, Takeda K, Iso K, Qian Y, Morimoto Y, Adachi T, Hirose H, Yokoyama Y, Ogino T, Miyoshi N, Takahashi H, Uemura M, Mizushima T, Hinoi T, Mori M, Doki Y, Eguchi H, Yamamoto H. Tumor-suppressive role of the musculoaponeuroticfibrosarcoma gene in colorectal cancer. iScience. 2023 Mar 23;26(4):106478. doi: 10.1016/j.isci.2023.106478. PMID: 37091240; PMCID: PMC10119606.
Takenaka W, Yokoyama Y, Ikehata K, Kouda S, Hirose H, Minami K, Hamada Y, Mori S, Koizumi M, Yamamoto H. KRT13 is upregulated in pancreatic cancer stem-like cells and associated with radioresistance. J Radiat Res. 2023 Mar 23;64(2):284-293. doi: 10.1093/jrr/rrac091. PMID: 36610719; PMCID: PMC10036105.
Morimoto Y, Yamashita N, Hirose H, Fushimi A, Haratake N, Daimon T, Bhattacharya A, Ahmad R, Suzuki Y, Takahashi H, Kufe DW. MUC1-C is necessary for SHP2 activation and BRAF inhibitor resistance in BRAF(V600E) mutant colorectal cancer. Cancer Lett. 2023 Apr 10;559:216116. doi: 10.1016/j.canlet.2023.216116. Epub 2023 Mar 5. PMID: 36878307.
Morimoto Y, Yamashita N, Daimon T, Hirose H, Yamano S, Haratake N, Ishikawa S, Bhattacharya A, Fushimi A, Ahmad R, Takahashi H, Dashevsky O, Mitsiades C, Kufe D. MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells. J Immunother Cancer. 2023 Feb;11(2):e006238. doi: 10.1136/jitc-2022-006238. PMID: 36754452; PMCID: PMC9923360.
Ozato Y, Kojima Y, Kobayashi Y, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Kagawa K, Goto Y, Utou M, Fukunaga M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Niida A, Hirose H, Hayashi S, Koseki J, Oki E, Fukuchi S, Murakami K, Tobo T, Nagayama S, Uemura M, Sakamoto T, Oshima M, Doki Y, Eguchi H, Mori M, Iwasaki T, Oda Y, Shibata T, Suzuki Y, Shimamura T, Mimori K. Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer. Cell Rep. 2023 Jan 31;42(1):111929. doi: 10.1016/j.celrep.2022.111929. Epub 2023 Jan 18. PMID: 36656712.
Inukai K, Kise K, Hayashi Y, Jia W, Muramatsu F, Okamoto N, Konishi H, Akuta K, Kidoya H, Takakura N. Cancer apelin receptor suppresses vascular mimicry in malignant melanoma. Pathol Oncol Res. 2023 Jan 27;29:1610867. doi: 10.3389/pore.2023.1610867. PMID: 36776217; PMCID: PMC9912982.